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It is f or this reason that in accordance with the present invention the active principle carried by the nanocapsules is preferably chosen from the anti-viral agents: these are in particular acyclovir or iododeoxy uridine; and the ocular effects of viral diseases can thus be effectively checked.

It goes without saying that in accordance with the present invention a plurality of active principles can be used in combination in the said nanocapsules.

In fact, all molecules, whether of lipophilic or hydrophilic nature, can be incorporated in the nanocapsules of the present invention. This constitutes a considerable additional advantage, since it is known that certain active principles necessary however for the prevention or cure of particular eye diseases cannot, because of their lipophilic nature, be incorporated in conventional collyria. This advantage results from the conventional process for preparing the nanocapsules, as appears for example in EP , and in the following steps:.

Preferably, in accordance with the present invention, before step a , the salt of the active, principle is converted to the non-ionized form of the said active principle. The polymer used in step b of the process of the present invention is preferably polyepsiloncaprolactone, but other appropriate polymers may be used polyacrylic derivatives, etc.

The result of the said preparation process is that the ophthalmic products of the present invention supply the active principle in its non-ionized form, insoluble in water and thus insoluble in a conventional collyrium. Furthermore, the fact that the active principle is dissolved in an oil allows it to be protected from the action of the lachrymal fluid which could re-ionize it and thus cause it to lose its lipophilic nature.

This non-ionized form is advantageously retained by the lipophilic epithelium to reach the aqueous stroma. Once in the said stroma, the active principle can take up its hydrophilic form again.

In fact, at the pH of the stroma approximately 7 the active principle takes up its ionized form again and again becomes soluble in aqueous medium, allowing it to diffuse across the stroma.

The results obtained following the experiments carried out with the ophthalmic products of the present invention are surprising: for a considerably increased therapeutic effect which lasts longer in time, the quantities of active principle used are approximately at most a fifth of that of commercially available collyria.

At the same time, a decrease in the undesirable side effects is observed. Consequently, thanks to the ophthalmic products of the present invention, it will be possible to:. The present invention also relates to the application of nanocapsules for preparing ophthalmic products, namely on the one hand products intended for tonical ocular or peri-ocular use, such as collyria, and on the other hand products intended for systemic ocular or peri-ocular administration.

In fact, in accordance with the present invention it is possible to make use of all the means of administration used in ophthalmology, such as sub-conjunctival or intra-vitreous administration. Thus, shadowgraph studies carried out during an intra-vitreous administration of the nanocapsules of the present invention show that the said capsules remain in the vitreous humour for at least 48 to 72 hours.

Given that currently at least two intra-vitreous administrations per day are required to treat someone suffering from AIDS, one can imagine the scope of progress enabled by the ophthalmic products of the present invention, since the number of intra-vitreous injections required is considerably reduced.

The present invention is illustrated by the following non-restrictive examples. Finally, after separation by decanting, the chloroform phase is dried and the active principle crystallizes. Homogenization is carried out for 5 minutes. Then the suspension formed is evaporated in vacuo until a final volume of 5 ml is reached. The oil containing the carteolol is mixed with the acetone containing the polycaprolactone, with stirring rpm.

Then, the acetone containing the polycaprolactone, the oil and the carteolol is added with magnetic stirring rpm to 50 ml of water pH 7 containing 0. Finally, the suspension formed is evaporated in vacuo until a final volume of 5 ml is reached. Then, the acetone containing the polycaprolactone, the oil and the indium oxinate is added with magnetic stirring rpm to 50 ml of water at pH 7 containing 0.

These tests were carried out with the aid of two beta-blockers used in the treatment of intraocular hypertension or glaucoma. In order to reduce the intraocular hypertension, these molecules have to penetrate the eyeball. The penetration of the medicament into the eye, after instillation at the level of the conjunctival sac, is a direct function of the time it remains in contact with the eye.

This contact time is very small with the collyria currently commercially available. When the same product is incorporated in the ophthalmic product of the present invention, it remains in contact with the eye for much longer. This increase in the time of local residence is demonstrated by gamma-shadowgraph studies and by measuring the therapeutic effect. The therapeutic effect is measured directly in the rabbit which was given glaucoma by injecting chymotrypsin into the eye with the aid of an aplanatic ionometer.

The two active principles tested are currently used in the treatment of glaucoma. The results obtained are shown in the FIGS. These FIGURES show the chronological evolution of intraocular pressure after instillation of the commercial collyrium containing either 0. In order to demonstrate the secondary cardiovascular effects following instillation of the beta-blocker collyria, the cardiovascular system of the rabbit is stimulated by a single administration of a dose of isoprenaline 2.

The result of this administration is an increase in the heart rate and a decrease in arterial pressure. This leads to beta-blocking of the general cardiovascular system and may be the cause of the side effects such as severe cardiac disorders and subsequently cerebro-vascular illnesses. Under the same conditions, the instillation of the ophthalmic products of the present invention containing carteolol at a dose of only a fifth 0.

Thus, the incidence of undesirable illnesses is reduced to a very considerable extent. These results are shown in diagrammatic form in FIG. The ophthalmic products of the present invention are marked with the aid of a gamma emitter, indium oxinate, and monitored by a gamma camera after instillation into the eye of the rabbit.

At the same time, the indium solution simulating the collyrium control is instilled in the other eye and monitored by the same camera. In conclusion, the ophthalmic products of the present invention allow the contact time of a medicament in the eye to be extended and to deliver the active principle in the non-ionized form, which penetrates across the cornea better.

They thus significantly improve its efficacity. The use of polymers already used in other sectors of health care and considered as biocompatible provides a basic guarantee of the absence of toxicity of the nanocapsules. On the other hand, their tolerance in the rabbit was satisfactory. In time, all the active principles used in ophthalmology antibiotics, anti-viral agents, anti-inflammatory agents, etc. All rights reserved. Login Sign up. Search Expert Search Quick Search.

Ophthalmic product. United States Patent Ophthalmic product comprising nanocapsules, process for preparing it and application of the nanocapsules. American Based Eye Pharmaceutical Company. This article is about the medical company.

For other uses, see Alcon disambiguation. Traded as. Switzerland [1]. Surgical products Contact lenses Over-the-counter products. Operating income. Net income. Retrieved December 5, Securities and Exchange Commission. Retrieved The New York Times. Archived from the original on 6 January San Antonio Business Journal. Business Wire. March 29, Retrieved March 16, The Chief Executive Forum. Archived from the original on April 9, Swissinfo in French.

Wikimedia Commons has media related to Alcon. Swiss Market Index companies of Switzerland. Swiss Leader Index companies of Switzerland. Pharmaceutical companies of the United States.

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Torres Y Ribelles S. Panjiva MENU. See Alcon Cusi SA 's products and customers Thousands of companies like you use Panjiva to research suppliers and competitors. Request a Demo. Easy access to trade data U. Customs records organized by company U. Shipment data shows what products a company is trading and more.

Learn more. Explore trading relationships hidden in supply chain data Supply chain map. See all 6 customers of Alcon Cusi SA. Inside Counsel 0 Go Pro to view corporate inside counsel. Assignor Trademark Corporate Family 0 Alcon Cusi, S. Sign in to add additional links. Incoming Payments This organization has not disclosed any incoming payments from lobbying groups.

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See all 6 customers of Alcon Cusi SA. Contact information for Alcon Cusi SA. Sign up to access. Top HS Codes HS 30 - Pharmaceutical products HS 48 - Paper and paperboard; articles of paper pulp, of paper or paperboard HS 33 - Essential oils and resinoids; perfumery, cosmetic or toilet preparations HS 39 - Plastics and articles thereof HS 90 - Optical, photographic, cinematographic, measuring, checking, medical or surgical instruments and apparatus; parts and accessories.

See more goods shipped on Panjiva. Sample Bill of Lading shipment records available Date. Thousands of companies use Panjiva to research suppliers and competitors Request a Demo. Company Blog Press Contact Jobs. Alcon Canada Inc. Bill of lading. Thanks for your patience! Inside Counsel 0 Go Pro to view corporate inside counsel. Assignor Trademark Corporate Family 0 Alcon Cusi, S. Sign in to add additional links. Incoming Payments This organization has not disclosed any incoming payments from lobbying groups.

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